Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.41 |
| ▸ | JAK3 | P52333 | 8/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15210836 | 0.78 | JAK2 (0.49) | JAK2JAK3PTK2EGFRFLT1 | |
| SCHEMBL15210529 | 0.74 | JAK2 (0.55) | JAK2JAK3PTK2 | |
| SCHEMBL15210962 | 0.68 | JAK2 (0.40) | JAK2JAK3PTK2EGFRFLT1 | |
| SCHEMBL20593 | 0.64 | JAK2 (0.52) | JAK2JAK3PTK2 | |
| SCHEMBL16394496 | 0.63 | JAK2 (0.51) | JAK2JAK3 | |
| SCHEMBL20626 | 0.63 | JAK2 (0.59) | JAK2JAK3PTK2 | |
| SCHEMBL20318 | 0.63 | MAPT (0.59) | JAK2JAK3PTK2EGFR | |
| SCHEMBL16394396 | 0.62 | JAK2 (0.49) | JAK2JAK3PTK2 | |
| SCHEMBL13535777 | 0.61 | JAK2 (0.77) | JAK2JAK3PTK2 | |
| SCHEMBL16394348 | 0.60 | JAK2 (0.63) | JAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817310-B1 | 8-SUBSTITUTED 2-AMINO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-21 | — | — | EP | disclosed |