Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 12/20 | 0.34 |
| ▸ | JAK1 | P23458 | 5/20 | 0.34 |
| ▸ | JAK3 | P52333 | 6/20 | 0.34 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.34 |
| ▸ | MARK3 | P27448 | 2/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15210740 | 0.90 | SYK (0.51) | SYKEIF2AK4LCKBRAFKDR | |
| SCHEMBL15212586 | 0.89 | SYK (0.50) | SYKEIF2AK4LCKBRAFKDR | |
| SCHEMBL16394673 | 0.89 | SYK (0.50) | SYKEIF2AK4LCKBRAFKDR | |
| SCHEMBL15210597 | 0.88 | SYK (0.47) | SYKEIF2AK4LCKBRAFKDR | |
| SCHEMBL16407143 | 0.86 | SYK (0.48) | SYKEIF2AK4LCKBRAFKDR | |
| SCHEMBL15210734 | 0.85 | SYK (0.47) | SYKEIF2AK4LCKBRAFKDR | |
| SCHEMBL15210624 | 0.85 | SYK (0.47) | SYKEIF2AK4LCKBRAFKDR | |
| SCHEMBL15210712 | 0.84 | SYK (0.45) | SYKEIF2AK4LCKBRAFKDR | |
| SCHEMBL16407154 | 0.83 | SYK (0.44) | SYKEIF2AK4LCKBRAFKDR | |
| SCHEMBL15210547 | 0.83 | CAMK1D (0.49) | SYKEIF2AK4LCKBRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817310-B1 | 8-SUBSTITUTED 2-AMINO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-21 | — | — | EP | disclosed |