Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 19/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19982953 | 0.92 | SYK (0.44) | SYKEIF2AK4JAK2 | |
| SCHEMBL15210630 | 0.92 | SYK (0.44) | SYKEIF2AK4JAK2 | |
| SCHEMBL19982969 | 0.87 | SYK (0.43) | SYKEIF2AK4NTRK1NTRK3NTRK2 | |
| SCHEMBL16394434 | 0.87 | SYK (0.43) | SYKEIF2AK4NTRK1NTRK3NTRK2 | |
| SCHEMBL15221226 | 0.87 | SYK (0.43) | SYKEIF2AK4NTRK1NTRK3NTRK2 | |
| SCHEMBL15210775 | 0.85 | SYK (0.46) | SYKEIF2AK4JAK2 | |
| SCHEMBL19970667 | 0.85 | SYK (0.48) | SYKEIF2AK4JAK2 | |
| SCHEMBL19970666 | 0.85 | SYK (0.48) | SYKEIF2AK4JAK2 | |
| SCHEMBL15221229 | 0.83 | SYK (0.45) | SYKEIF2AK4JAK2 | |
| SCHEMBL16394841 | 0.83 | SYK (0.46) | SYKEIF2AK4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817310-B1 | 8-SUBSTITUTED 2-AMINO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-21 | — | — | EP | disclosed |