Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 16/20 | 0.33 |
| ▸ | JAK3 | P52333 | 14/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 13/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21403 | 0.87 | SYK (0.42) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL15210682 | 0.85 | JAK3 (0.50) | JAK2JAK3PTK2 | |
| SCHEMBL20713 | 0.81 | SYK (0.58) | SYKEIF2AK4 | |
| SCHEMBL15210836 | 0.79 | JAK2 (0.49) | JAK2JAK3PTK2 | |
| SCHEMBL16394496 | 0.78 | JAK2 (0.51) | SYKEIF2AK4JAK2JAK3 | |
| SCHEMBL16407112 | 0.76 | SYK (0.42) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL15210557 | 0.74 | SYK (0.57) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL15210962 | 0.74 | JAK2 (0.40) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL15221151 | 0.73 | JAK2 (0.46) | JAK2JAK3PTK2 | |
| SCHEMBL20459 | 0.72 | SYK (0.42) | SYKEIF2AK4JAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817310-B1 | 8-SUBSTITUTED 2-AMINO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-21 | — | — | EP | disclosed |