Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.44 |
| ▸ | JAK3 | P52333 | 17/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 9/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15221168 | 0.84 | KDR (0.39) | JAK2JAK3PTK2SYKEIF2AK4 | |
| SCHEMBL15212646 | 0.80 | JAK2 (0.55) | JAK2JAK3PTK2SYK | |
| SCHEMBL15210695 | 0.79 | JAK2 (0.58) | JAK2JAK3PTK2 | |
| SCHEMBL15210689 | 0.78 | JAK2 (0.41) | JAK2JAK3PTK2SYKEIF2AK4 | |
| SCHEMBL15210810 | 0.78 | JAK2 (0.58) | JAK2JAK3PTK2 | |
| SCHEMBL15210487 | 0.78 | PSEN1 (0.47) | JAK2JAK3PTK2SYKEIF2AK4 | |
| SCHEMBL21968 | 0.78 | JAK2 (0.54) | JAK2JAK3PTK2 | |
| SCHEMBL15221161 | 0.77 | JAK2 (0.41) | JAK2JAK3PTK2SYKEIF2AK4 | |
| SCHEMBL15212684 | 0.77 | JAK2 (0.53) | JAK2JAK3PTK2 | |
| SCHEMBL15221151 | 0.77 | JAK2 (0.46) | JAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817310-B1 | 8-SUBSTITUTED 2-AMINO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-21 | — | — | EP | disclosed |