Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.44 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 10/20 | 0.39 |
| ▸ | JAK1 | P23458 | 7/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | WEE1 | P30291 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15210786 | 0.85 | SYK (0.46) | SYKEIF2AK4JAK2JAK1LCK | |
| SCHEMBL19982806 | 0.83 | SYK (0.49) | SYKEIF2AK4JAK2JAK1LCK | |
| SCHEMBL15210751 | 0.80 | SYK (0.45) | SYKEIF2AK4JAK2JAK1LCK | |
| SCHEMBL15210999 | 0.79 | SYK (0.50) | SYKEIF2AK4JAK2JAK1LCK | |
| SCHEMBL15210766 | 0.79 | BRD4 (0.45) | SYKEIF2AK4JAK2JAK1 | |
| SCHEMBL15221154 | 0.79 | SYK (0.47) | SYKEIF2AK4JAK2JAK1LCK | |
| SCHEMBL19982819 | 0.79 | SYK (0.51) | SYKEIF2AK4JAK2JAK1LCK | |
| SCHEMBL15221172 | 0.79 | SYK (0.46) | SYKEIF2AK4JAK2JAK1LCK | |
| SCHEMBL16394373 | 0.79 | SYK (0.49) | SYKEIF2AK4JAK2JAK1LCK | |
| SCHEMBL15221186 | 0.79 | SYK (0.49) | SYKEIF2AK4JAK2JAK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817310-B1 | 8-SUBSTITUTED 2-AMINO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-21 | — | — | EP | disclosed |