Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 8/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD5 | P21918 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2765998 | 0.86 | MIF (0.70) | MIFHDAC3HDAC1HDAC2NPC1 | |
| SCHEMBL2766991 | 0.85 | MIF (0.74) | MIFHDAC3HDAC1HDAC2HSD17B3 | |
| SCHEMBL2766883 | 0.82 | MIF (0.60) | MIFHDAC3HDAC1HDAC2MAPKAPK2 | |
| SCHEMBL2766942 | 0.82 | MIF (0.60) | MIFHDAC3HDAC1HDAC2HSD17B3 | |
| SCHEMBL3551113 | 0.81 | MIF (0.58) | MIFHDAC3HDAC1HDAC2HSD17B3 | |
| SCHEMBL26938963 | 0.81 | MIF (0.67) | MIFHDAC3HDAC1HDAC2HSD17B3 | |
| SCHEMBL2765855 | 0.80 | MIF (0.63) | MIFHDAC3HDAC1HDAC2NPC1 | |
| SCHEMBL3547917 | 0.80 | MIF (0.67) | MIFHDAC3HDAC1HDAC2HSD17B3 | |
| SCHEMBL24398658 | 0.79 | MIF (0.62) | MIFHDAC3HDAC1HDAC2HSD17B3 | |
| SCHEMBL2766423 | 0.79 | MIF (0.59) | MIFHDAC3HDAC1HDAC2HSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2944310-B1 | MIF inhibitors for the acute or chronic treatment of pulmonary hypertension | MIFCARE (FR) | 2018-03-21 | — | — | EP | disclosed |