Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14828708 | 1.00 | NR1H2 (0.45) | NR1H2CHRM2CHRM1CHRM3TSHR | |
| SCHEMBL25626705 | 1.00 | NR1H2 (0.45) | NR1H2CHRM2CHRM1CHRM3TSHR | |
| SCHEMBL30646926 | 0.88 | NR1H2 (0.41) | NR1H2CHRM2CHRM1CHRM3TSHR | |
| SCHEMBL15033787 | 0.87 | NR1H2 (0.56) | NR1H2CHRM2CHRM1CHRM3TSHR | |
| SCHEMBL17331292 | 0.87 | NR1H2 (0.56) | NR1H2CHRM2CHRM1CHRM3TSHR | |
| SCHEMBL10152546 | 0.86 | NR1H2 (0.44) | NR1H2CHRM2CHRM1CHRM3TSHR | |
| SCHEMBL28576704 | 0.86 | NR1H2 (0.44) | NR1H2CHRM2CHRM1CHRM3TSHR | |
| SCHEMBL21369480 | 0.86 | NR1H2 (0.44) | NR1H2CHRM2CHRM1CHRM3TSHR | |
| SCHEMBL22943927 | 0.84 | NR1H2 (0.40) | NR1H2CHRM2CHRM1CHRM3GPR119 | |
| SCHEMBL25339238 | 0.84 | NR1H2 (0.43) | NR1H2CHRM2CHRM1CHRM3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018051107-A1 | FLUOROHYDROXYPROLINE DERIVATIVES USEFUL IN THE PREPARATION OF PROTEOLYSIS TARGETED CHIMERAS | UNIVERSITY OF DUNDEE (GB) | 2018-03-22 | — | — | WO | disclosed |