SCHEMBL19985756 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	HSD17B10	Q99714	1/20	0.40

▸	CHRM2	P08172	1/20	0.40

▸	CHRM1	P11229	1/20	0.40

▸	CHRM3	P20309	1/20	0.40

▸	HPGD	P15428	1/20	0.40

▸	SMN1; SMN2	Q16637	2/20	0.39

▸	USP2	O75604	1/20	0.39

▸	RECQL	P46063	1/20	0.38

▸	EPHX1	P07099	1/20	0.38

▸	PREP	P48147	1/20	0.36

▸	NPC1	O15118	1/20	0.36

▸	GPR119	Q8TDV5	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL27929976	0.84	HSD17B10 (0.41)	HSD17B10CHRM2CHRM1CHRM3HPGD
SCHEMBL13415865	0.84	CHRM2 (0.47)	HSD17B10CHRM2CHRM1CHRM3HPGD
SCHEMBL21408129	0.84	CHRM2 (0.47)	HSD17B10CHRM2CHRM1CHRM3HPGD
SCHEMBL17343011	0.84	CHRM2 (0.47)	HSD17B10CHRM2CHRM1CHRM3HPGD
SCHEMBL20054305	0.84	CHRM2 (0.47)	HSD17B10CHRM2CHRM1CHRM3HPGD
SCHEMBL29906095	0.82	NR1H2 (0.39)	HSD17B10CHRM2CHRM1CHRM3HPGD
SCHEMBL24069887	0.81	USP2 (0.46)	HSD17B10CHRM2CHRM1CHRM3HPGD
SCHEMBL28923159	0.81	USP2 (0.46)	HSD17B10CHRM2CHRM1CHRM3HPGD
SCHEMBL15731577	0.81	CHRM2 (0.45)	HSD17B10CHRM2CHRM1CHRM3HPGD
SCHEMBL2198040	0.81	CHRM2 (0.45)	HSD17B10CHRM2CHRM1CHRM3HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2018051107-A1	FLUOROHYDROXYPROLINE DERIVATIVES USEFUL IN THE PREPARATION OF PROTEOLYSIS TARGETED CHIMERAS	UNIVERSITY OF DUNDEE (GB)	2018-03-22	—	—	WO	disclosed