SCHEMBL19986346

SCHEMBL19986346

CC/C=C\Oc1ccc(-c2ccc(C3CCCCC3)cc2)c(F)c1F

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.38
CYP2C9 P11712 1/20 0.38
APP P05067 1/20 0.38
S1PR1 P21453 3/20 0.35
FFAR4 Q5NUL3 1/20 0.33
SIGMAR1 Q99720 1/20 0.32
NOS3 P29474 2/20 0.31
NOS1 P29475 2/20 0.31
NOS2 P35228 2/20 0.31
FPR2 P25090 1/20 0.31
HSP90AA1 P07900 1/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31
KMT2A Q03164 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
NOTUM Q6P988 1/20 0.31
S1PR5 Q9H228 1/20 0.31
DGAT1 O75907 1/20 0.31
PTGDR Q13258 1/20 0.30
PTGDR2 Q9Y5Y4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19985417 0.89 ESR2 (0.35) FPR2
SCHEMBL19986351 0.86 CYP3A4 (0.40) CYP3A4CYP2C9APPS1PR1FFAR4
SCHEMBL15723069 0.86 CYP2C9 (0.39) CYP2C9MAPTKMT2ADGAT1
SCHEMBL19985444 0.84 CYP2C9 (0.33) CYP2C9GAAMAPTKMT2ADGAT1
SCHEMBL15726830 0.83 FASN (0.42) CYP3A4CYP2C9APPFPR2
SCHEMBL19985463 0.83 MAPT (0.33) CYP3A4CYP2C9GAAMAPTKMT2A
SCHEMBL19985449 0.83 MAPT (0.33) CYP3A4CYP2C9GAAMAPTKMT2A
SCHEMBL15681366 0.82 CYP3A4 (0.43) CYP3A4CYP2C9APPS1PR1FFAR4
SCHEMBL19986349 0.81 CYP3A4 (0.39) CYP3A4CYP2C9APPS1PR1FFAR4
SCHEMBL16769035 0.81 CYP3A4 (0.41) CYP3A4CYP2C9APPS1PR1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180079959-A1 LIQUID CRYSTAL ELEMENT WITH NEGATIVE DIELECTRIC ANISOTROPY DIC CORPORATION (JP) 2018-03-22 US disclosed