Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | NR2C2 | P49116 | 2/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | HCK | P08631 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | DDR1 | Q08345 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14704588 | 0.90 | MAPK14 (0.56) | HTTMAPK1ATMNR2C2CLK1 | |
| SCHEMBL16810188 | 0.89 | DDR1 (0.56) | HTTMAPK1ATMNR2C2CLK1 | |
| SCHEMBL20682530 | 0.88 | DDR1 (0.53) | HTTMAPK1ATMNR2C2CLK1 | |
| SCHEMBL3311056 | 0.88 | NR1H2 (0.52) | HTTMAPK1ATMNR2C2CLK1 | |
| SCHEMBL12516831 | 0.87 | DDR1 (0.52) | HTTMAPK1ATMNR2C2CLK1 | |
| SCHEMBL2313005 | 0.86 | RET (0.51) | HTTMAPK1ATMCLK1KIT | |
| SCHEMBL3942805 | 0.85 | MAPT (0.51) | HTTMAPK1ATMNR2C2CLK1 | |
| Hydrochloric Acid SCHEMBL393146 | 0.85 | RET (0.50) | HTTMAPK1ATMCLK1KIT | |
| Hydrochloric Acid SCHEMBL3562574 | 0.84 | RET (0.49) | HTTMAPK1ATMCLK1KIT | |
| SCHEMBL20577963 | 0.82 | HTT (0.57) | HTTMAPK1ATMNR2C2CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2018-03-21 | — | — | EP | disclosed |