Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.57 |
| ▸ | GAA | P10253 | 6/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1996810 | 0.90 | MEN1 (0.55) | MAPTGAARXFP1MEN1KMT2A | |
| SCHEMBL2000452 | 0.84 | MAPT (0.56) | MAPTGAARXFP1MEN1KMT2A | |
| SCHEMBL1996799 | 0.81 | MAPT (0.51) | MAPTGAARXFP1MEN1KMT2A | |
| SCHEMBL1998056 | 0.81 | MAPT (0.51) | MAPTGAARXFP1MEN1KMT2A | |
| SCHEMBL2001642 | 0.81 | RXFP1 (0.54) | MAPTGAARXFP1ALDH1A1KDM4E | |
| SCHEMBL2003685 | 0.81 | MAPT (0.53) | MAPTGAAALDH1A1KDM4EGLA | |
| SCHEMBL1996888 | 0.80 | MAPT (0.52) | MAPTGAARXFP1MEN1KMT2A | |
| SCHEMBL1996879 | 0.80 | GFER (0.58) | MAPTRXFP1MEN1KMT2AALDH1A1 | |
| SCHEMBL2003775 | 0.79 | CNR1 (0.69) | MAPTGAAALDH1A1KDM4EGLA | |
| SCHEMBL1997619 | 0.75 | MAPT (0.57) | MAPTGAARXFP1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960376-B2 | Benzo-fused heterocycles | CARA THERAPEUTICS, INC. (US) | 2011-06-14 | — | — | US | disclosed |