Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 1.00 |
| ▸ | MAP3K7 | O43318 | 10/20 | 1.00 |
| ▸ | MAP4K2 | Q12851 | 10/20 | 1.00 |
| ▸ | MAP3K20 | Q9NYL2 | 8/20 | 1.00 |
| ▸ | CSK | P41240 | 5/20 | 1.00 |
| ▸ | EPHA2 | P29317 | 3/20 | 1.00 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.79 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.79 |
| ▸ | ABL1 | P00519 | 2/20 | 0.79 |
| ▸ | RAF1 | P04049 | 2/20 | 0.79 |
| ▸ | LYN | P07948 | 2/20 | 0.79 |
| ▸ | SRC | P12931 | 2/20 | 0.79 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.79 |
| ▸ | ABL2 | P42684 | 2/20 | 0.79 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.79 |
| ▸ | FES | P07332 | 3/20 | 0.68 |
| ▸ | FER | P16591 | 3/20 | 0.68 |
| ▸ | FLT3 | P36888 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17515255 | 0.90 | DDR1 (0.95) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL2284120 | 0.89 | DDR1 (1.00) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL2284510 | 0.88 | MAPK14 (1.00) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL2284518 | 0.88 | MAPK14 (1.00) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL29725987 | 0.88 | MAPK14 (1.00) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL14704592 | 0.88 | MAPK14 (0.78) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL16786132 | 0.87 | MAPK14 (0.95) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL12518526 | 0.86 | DDR1 (0.82) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL30692242 | 0.86 | DDR1 (0.82) | MAPK14MAP3K7MAP4K2MAP3K20CSK | |
| SCHEMBL17208613 | 0.86 | MAP3K20 (0.81) | MAPK14MAP3K7MAP4K2MAP3K20CSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2018-03-21 | — | — | EP | disclosed |