Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.57 |
| ▸ | FLT4 | P35916 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | RARB | P10826 | 1/20 | 0.57 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | DPP4 | P27487 | 6/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19971407 | 1.00 | KMT2A (0.65) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL29979989 | 1.00 | KMT2A (0.65) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL19986996 | 0.89 | KMT2A (0.63) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL19971486 | 0.89 | KMT2A (0.63) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL19971423 | 0.88 | EPHA2 (0.63) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL19971379 | 0.88 | EPHA2 (0.63) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL19971441 | 0.88 | EPHA2 (0.63) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL19986895 | 0.88 | EPHA2 (0.63) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL9536271 | 0.88 | KMT2A (0.66) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL9535116 | 0.86 | KMT2A (0.62) | KMT2AEPHA2FLT4GSK3BRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512849-B1 | 7-SUBSTITUTED 1-ARYL-NAPHTHYRIDIN-3-CARBOXAMIDES AND THEIR USE | BAYER AG (DE) | 2021-06-23 | — | — | EP | disclosed |
| WO-2018050510-A1 | 7-SUBSTITUTED 1-ARYL-NAPHTHYRIDINE-3-CARBOXYLIC ACID AMIDES AND USE THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2018-03-22 | — | — | WO | disclosed |