SCHEMBL19986920

SCHEMBL19986920

CC1CCC(Nc2ccc3ncc(-c4cccc(Cl)c4)n3n2)CC1

nearest known ligand 0.82

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PIM1 P11309 20/20 0.82
KCNH2 Q12809 1/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL138855 0.90 PIM1 (1.00) PIM1KCNH2
SCHEMBL103197 0.90 PIM1 (1.00) PIM1KCNH2
SCHEMBL103173 0.90 PIM1 (1.00) PIM1KCNH2
SCHEMBL19986988 0.90 PIM1 (0.84) PIM1KCNH2
SCHEMBL103260 0.89 PIM1 (1.00) PIM1KCNH2
SCHEMBL14638741 0.89 PIM1 (1.00) PIM1KCNH2
SCHEMBL19986912 0.89 PIM1 (0.82) PIM1KCNH2
SCHEMBL136164 0.89 PIM1 (1.00) PIM1KCNH2
SCHEMBL136163 0.89 PIM1 (1.00) PIM1KCNH2
SCHEMBL16210904 0.89 PIM1 (1.00) PIM1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2734205-B1 HETEROCYCLIC PROTEIN KINASE INHIBITORS TOLERO PHARMACEUTICALS INC (US) 2018-03-21 EP disclosed