Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 5/20 | 0.74 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.74 |
| ▸ | DYRK3 | O43781 | 4/20 | 0.69 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.69 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.69 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.69 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.69 |
| ▸ | CDK9 | P50750 | 3/20 | 0.69 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.69 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.69 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.69 |
| ▸ | CDK2 | P24941 | 2/20 | 0.69 |
| ▸ | PIM1 | P11309 | 11/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19987123 | 0.87 | DYRK3 (0.69) | FYNDYRK3DYRK1ADYRK2DYRK1B | |
| SCHEMBL23299224 | 0.85 | FYN (0.76) | FYNMKNK1DYRK3DYRK1ADYRK2 | |
| SCHEMBL16010275 | 0.85 | FYN (1.00) | FYNMKNK1 | |
| SCHEMBL30521845 | 0.85 | FYN (1.00) | FYNMKNK1 | |
| SCHEMBL16009706 | 0.83 | FYN (0.74) | FYNMKNK1 | |
| SCHEMBL16009532 | 0.82 | FYN (0.73) | FYNMKNK1DYRK1APIM1 | |
| SCHEMBL102942 | 0.82 | DYRK1A (1.00) | FYNDYRK3DYRK1ADYRK2DYRK1B | |
| SCHEMBL2946476 | 0.81 | FYN (0.60) | FYNMKNK1DYRK3DYRK1ADYRK2 | |
| SCHEMBL2943786 | 0.81 | MKNK1 (0.76) | FYNMKNK1DYRK3DYRK1ADYRK2 | |
| SCHEMBL29781258 | 0.81 | FYN (0.70) | FYNMKNK1DYRK3DYRK1ADYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409278-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2020-09-16 | — | — | EP | disclosed |
| EP-2734205-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2018-03-21 | — | — | EP | disclosed |