Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 12/20 | 0.61 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.58 |
| ▸ | FLT3 | P36888 | 2/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19987117 | 0.85 | PIM1 (0.58) | PIM1PIM2FLT3ADORA2AADORA1 | |
| SCHEMBL8207947 | 0.85 | PIM1 (0.61) | PIM1PIM2FLT3ADORA2AADORA1 | |
| SCHEMBL103371 | 0.85 | PIM1 (0.58) | PIM1PIM2FLT3ADORA2AADORA1 | |
| SCHEMBL14653595 | 0.81 | PIM1 (0.63) | PIM1PIM2FLT3ADORA2AADORA1 | |
| SCHEMBL23299247 | 0.80 | PIM1 (0.65) | PIM1PIM2ADORA1HPGDNPC1 | |
| SCHEMBL13501066 | 0.80 | PIM1 (0.65) | PIM1PIM2FLT3NPC1RAB9A | |
| SCHEMBL102493 | 0.76 | PIM1 (0.62) | PIM1PIM2FLT3HPGDKDM4E | |
| SCHEMBL19987090 | 0.76 | PIM1 (0.66) | PIM1PIM2FLT3TGFBR2 | |
| SCHEMBL19987012 | 0.76 | PIM1 (0.82) | PIM1PIM2FLT3 | |
| SCHEMBL19987094 | 0.76 | PIM1 (0.52) | PIM1PIM2FLT3HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409278-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2020-09-16 | — | — | EP | disclosed |
| EP-2734205-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2018-03-21 | — | — | EP | disclosed |