Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 16/20 | 0.76 |
| ▸ | PIM2 | Q9P1W9 | 12/20 | 0.76 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.48 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16210798 | 0.87 | PIM1 (1.00) | PIM1PIM2FLT3KCNH2 | |
| SCHEMBL102618 | 0.87 | PIM1 (1.00) | PIM1PIM2FLT3KCNH2 | |
| SCHEMBL14653595 | 0.80 | PIM1 (0.63) | PIM1PIM2FLT3KCNH2TGFBR2 | |
| SCHEMBL102845 | 0.80 | PIM1 (0.60) | PIM1PIM2FLT3KCNH2TGFBR2 | |
| SCHEMBL18362768 | 0.80 | PIM1 (0.78) | PIM1PIM2SMPD3 | |
| SCHEMBL1443512 | 0.79 | SMPD3 (0.62) | PIM1PIM2SMPD3 | |
| SCHEMBL19986964 | 0.78 | PIM1 (0.83) | PIM1PIM2FLT3KCNH2 | |
| SCHEMBL22421461 | 0.75 | PIM1 (0.54) | PIM1PIM2FLT3KCNH2TGFBR2 | |
| SCHEMBL4330227 | 0.75 | PIM1 (0.65) | PIM1PIM2FLT3KCNH2TGFBR2 | |
| SCHEMBL19494008 | 0.74 | SMPD3 (0.56) | PIM1PIM2SMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3812387-A1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | Sumitomo Dainippon Pharma Oncology, Inc. (US) | 2021-04-28 | — | — | EP | disclosed |
| EP-3409278-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2020-09-16 | — | — | EP | disclosed |
| EP-2734205-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2018-03-21 | — | — | EP | disclosed |