Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 19/20 | 0.84 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.84 |
| ▸ | GAK | O14976 | 1/20 | 0.64 |
| ▸ | STK10 | O94804 | 1/20 | 0.64 |
| ▸ | YES1 | P07947 | 1/20 | 0.64 |
| ▸ | RET | P07949 | 1/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.64 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.64 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.64 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.64 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.64 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.64 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.64 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.64 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.64 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.64 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.64 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19987113 | 0.92 | PIM1 (0.93) | PIM1KCNH2 | |
| SCHEMBL135844 | 0.91 | PIM1 (1.00) | PIM1KCNH2 | |
| SCHEMBL102397 | 0.91 | PIM1 (1.00) | PIM1KCNH2 | |
| SCHEMBL103184 | 0.91 | PIM1 (1.00) | PIM1KCNH2 | |
| SCHEMBL102533 | 0.90 | PIM1 (1.00) | PIM1KCNH2FYN | |
| SCHEMBL102682 | 0.90 | PIM1 (1.00) | PIM1KCNH2 | |
| SCHEMBL16211078 | 0.90 | PIM1 (1.00) | PIM1KCNH2 | |
| SCHEMBL19987030 | 0.89 | PIM1 (0.78) | PIM1KCNH2GAKSTK10YES1 | |
| SCHEMBL178304 | 0.89 | PIM1 (1.00) | PIM1KCNH2GAKSTK10YES1 | |
| SCHEMBL102129 | 0.89 | PIM1 (1.00) | PIM1KCNH2GAKSTK10YES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3812387-A1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | Sumitomo Dainippon Pharma Oncology, Inc. (US) | 2021-04-28 | — | — | EP | disclosed |
| US-10875864-B2 | Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors | SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. (US) | 2020-12-29 | — | — | US | disclosed |
| EP-3409278-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2020-09-16 | — | — | EP | disclosed |
| EP-2734205-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2018-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10875864-B2 | Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors | PIM2, PIM1, PIM3 | PIM1 2/4885KCNH2 1630/4885GAK 281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.