Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 16/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.83 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.77 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.77 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.63 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.60 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.59 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.59 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24736843 | 1.00 | PIM1 (0.83) | PIM1KCNH2PIM3PIM2MKNK1 | |
| SCHEMBL24736861 | 0.91 | PIM1 (0.93) | PIM1KCNH2PIM3PIM2CDK2 | |
| SCHEMBL29555648 | 0.91 | PIM1 (0.76) | PIM1KCNH2PIM3PIM2FYN | |
| SCHEMBL24736886 | 0.91 | PIM1 (0.76) | PIM1KCNH2PIM3PIM2FYN | |
| SCHEMBL24736850 | 0.91 | PIM1 (0.93) | PIM1KCNH2PIM3PIM2CDK2 | |
| SCHEMBL24737145 | 0.91 | PIM1 (0.93) | PIM1KCNH2PIM3PIM2CDK2 | |
| SCHEMBL24736863 | 0.91 | PIM1 (0.93) | PIM1KCNH2PIM3PIM2CDK2 | |
| SCHEMBL24736851 | 0.91 | PIM1 (0.79) | PIM1KCNH2PIM3PIM2FYN | |
| SCHEMBL24736841 | 0.91 | PIM1 (0.79) | PIM1KCNH2PIM3PIM2FYN | |
| SCHEMBL24737150 | 0.91 | PIM1 (0.79) | PIM1KCNH2PIM3PIM2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024097653-A1 | PIM1 INHIBITOR FOR TREATING MYELOPROLIFERATIVE NEOPLASMS | SUMITOMO PHARMA AMERICA, INC. (US) | 2024-05-10 | — | — | WO | disclosed |
| EP-3812387-A1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | Sumitomo Dainippon Pharma Oncology, Inc. (US) | 2021-04-28 | — | — | EP | disclosed |
| WO-2020198077-A1 | COMPOSITIONS COMPRISING PKM2 MODULATORS AND METHODS OF TREATMENT USING THE SAME | SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| EP-3409278-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2020-09-16 | — | — | EP | disclosed |
| WO-2019200254-A1 | PIM KINASE INHIBITORS FOR TREATMENT OF MYELOPROLIFERATIVE NEOPLASMS AND FIBROSIS ASSOCIATED WITH CANCER | TOLERO PHARMACEUTICALS, INC. (US) | 2019-10-17 | — | — | WO | disclosed |
| EP-2734205-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2018-03-21 | — | — | EP | disclosed |