Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 20/20 | 0.81 |
| ▸ | PIM2 | Q9P1W9 | 13/20 | 0.81 |
| ▸ | FLT3 | P36888 | 3/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL135092 | 0.89 | PIM1 (1.00) | PIM1PIM2FLT3 | |
| SCHEMBL102727 | 0.89 | PIM1 (1.00) | PIM1PIM2FLT3 | |
| SCHEMBL102862 | 0.89 | PIM1 (1.00) | PIM1PIM2FLT3 | |
| SCHEMBL16210821 | 0.89 | PIM1 (1.00) | PIM1PIM2FLT3 | |
| SCHEMBL102496 | 0.89 | PIM1 (1.00) | PIM1PIM2FLT3 | |
| SCHEMBL14639094 | 0.89 | PIM1 (1.00) | PIM1PIM2FLT3 | |
| SCHEMBL18355911 | 0.88 | PIM1 (0.79) | PIM1PIM2FLT3 | |
| SCHEMBL22421465 | 0.87 | PIM1 (0.62) | PIM1PIM2FLT3 | |
| SCHEMBL102495 | 0.87 | PIM1 (1.00) | PIM1PIM2FLT3 | |
| SCHEMBL178295 | 0.87 | PIM1 (1.00) | PIM1PIM2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409278-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2020-09-16 | — | — | EP | disclosed |
| EP-2734205-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2018-03-21 | — | — | EP | disclosed |