Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 19/20 | 0.77 |
| ▸ | PIM2 | Q9P1W9 | 14/20 | 0.77 |
| ▸ | FLT3 | P36888 | 3/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19986998 | 0.87 | PIM1 (0.79) | PIM1PIM2FLT3KCNH2RET | |
| SCHEMBL19986954 | 0.86 | PIM1 (0.76) | PIM1PIM2FLT3KCNH2RET | |
| SCHEMBL22421506 | 0.86 | PIM1 (0.61) | PIM1PIM2FLT3KCNH2RET | |
| SCHEMBL102722 | 0.86 | PIM1 (1.00) | PIM1PIM2FLT3KCNH2RET | |
| SCHEMBL102910 | 0.76 | PIM1 (1.00) | PIM1PIM2FLT3 | |
| SCHEMBL19987094 | 0.76 | PIM1 (0.52) | PIM1PIM2FLT3 | |
| SCHEMBL19987012 | 0.76 | PIM1 (0.82) | PIM1PIM2FLT3 | |
| SCHEMBL4594844 | 0.76 | RET (0.72) | PIM1PIM2FLT3RET | |
| SCHEMBL4878960 | 0.75 | PIM1 (0.79) | PIM1PIM2FLT3RET | |
| SCHEMBL102215 | 0.75 | PIM1 (1.00) | PIM1PIM2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3812387-A1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | Sumitomo Dainippon Pharma Oncology, Inc. (US) | 2021-04-28 | — | — | EP | disclosed |
| EP-2734205-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2018-03-21 | — | — | EP | disclosed |