Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R2 | O00459 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ULK1 | O75385 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19989495 | 0.93 | SMN1; SMN2 (0.44) | PIK3R2MAPTGAAMAPK1SMN1; SMN2 | |
| SCHEMBL19988976 | 0.88 | MAPT (0.45) | PIK3R2MAPTGAAMAPK1SMN1; SMN2 | |
| SCHEMBL19989021 | 0.87 | MAPT (0.49) | MAPTGAAMAPK1SMN1; SMN2TDP1 | |
| SCHEMBL19989075 | 0.87 | MAPT (0.40) | PIK3R2MAPTMAPK1SMN1; SMN2TDP1 | |
| SCHEMBL19988880 | 0.86 | MAPT (0.41) | PIK3R2MAPTGAAMAPK1SMN1; SMN2 | |
| SCHEMBL19988860 | 0.84 | PIK3R2 (0.44) | PIK3R2MAPTGAAMAPK1SMN1; SMN2 | |
| SCHEMBL19989175 | 0.83 | MAPT (0.48) | PIK3R2MAPTGAAMAPK1SMN1; SMN2 | |
| SCHEMBL19989256 | 0.83 | PIK3CA (0.41) | PIK3R2MAPTGAAMAPK1SMN1; SMN2 | |
| SCHEMBL19991570 | 0.83 | MAPT (0.41) | MAPTGAAMAPK1SMN1; SMN2TDP1 | |
| SCHEMBL19988989 | 0.82 | PIK3R2 (0.41) | PIK3R2MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086747-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2018-03-29 | — | — | US | disclosed |
| WO-2018057808-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2018-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086747-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PIK3CA, AKT3, TNNI3K | PIK3R2 18/4885MAPT 146/4885GAA 2943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.