Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R2 | O00459 | 13/20 | 0.66 |
| ▸ | PIK3C2B | O00750 | 4/20 | 0.58 |
| ▸ | AHR | P35869 | 1/20 | 0.52 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19988969 | 0.93 | PIK3R2 (0.64) | PIK3R2PIK3C2BAHRMOKKDM4E | |
| SCHEMBL19988866 | 0.91 | PIK3R2 (0.63) | PIK3R2PIK3C2BAHRMOKKDM4E | |
| SCHEMBL19989225 | 0.90 | PIK3R2 (0.66) | PIK3R2PIK3C2BMAPT | |
| SCHEMBL19988911 | 0.88 | PIK3R2 (0.70) | PIK3R2PIK3C2B | |
| SCHEMBL19988991 | 0.87 | PIK3R2 (0.52) | PIK3R2PIK3C2B | |
| SCHEMBL19989445 | 0.86 | PIK3R2 (0.65) | PIK3R2PIK3C2B | |
| SCHEMBL19988889 | 0.86 | PIK3R2 (0.67) | PIK3R2PIK3C2B | |
| SCHEMBL20009347 | 0.84 | PIK3C2B (0.70) | PIK3R2PIK3C2B | |
| SCHEMBL19988845 | 0.83 | PIK3R2 (0.64) | PIK3R2PIK3C2BMAPT | |
| SCHEMBL19991623 | 0.82 | PIK3C2B (0.60) | PIK3R2PIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086747-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2018-03-29 | — | — | US | disclosed |
| WO-2018057808-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2018-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086747-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PIK3CA, AKT3, TNNI3K | PIK3R2 18/4885PIK3C2B 20/4885AHR 4547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.