Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R2 | O00459 | 17/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19988995 | 0.92 | PIK3R2 (0.65) | PIK3R2PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL19989339 | 0.91 | PIK3R2 (0.64) | PIK3R2PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL19989218 | 0.84 | PIK3R2 (0.68) | PIK3R2 | |
| SCHEMBL19989364 | 0.82 | PIK3R2 (0.71) | PIK3R2PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL20000401 | 0.80 | PIK3R2 (0.77) | PIK3R2PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL19989371 | 0.76 | PIK3R2 (0.67) | PIK3R2 | |
| SCHEMBL19989246 | 0.75 | PIK3R2 (0.65) | PIK3R2PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL19989074 | 0.74 | PIK3R2 (0.64) | PIK3R2 | |
| SCHEMBL19988994 | 0.74 | PIK3R2 (0.67) | PIK3R2PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL19989377 | 0.74 | PIK3R2 (0.67) | PIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086747-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2018-03-29 | — | — | US | disclosed |
| WO-2018057808-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2018-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086747-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PIK3CA, AKT3, TNNI3K | PIK3R2 18/4885PIK3CD 6/4885PIK3R1 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.