Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19990022 | 0.91 | PIK3R2 (0.51) | PIK3R2 | |
| SCHEMBL19989866 | 0.89 | PIK3R2 (0.55) | PIK3R2 | |
| SCHEMBL19989949 | 0.88 | PIK3R2 (0.48) | PIK3R2 | |
| SCHEMBL19990055 | 0.87 | PIK3R2 (0.61) | PIK3R2 | |
| SCHEMBL19989914 | 0.85 | PIK3R2 (0.53) | PIK3R2 | |
| SCHEMBL19989881 | 0.84 | PIK3R2 (0.51) | PIK3R2 | |
| SCHEMBL19989988 | 0.84 | PIK3R2 (0.58) | PIK3R2 | |
| SCHEMBL19989911 | 0.83 | PIK3R2 (0.56) | PIK3R2 | |
| SCHEMBL19990066 | 0.82 | PIK3R2 (0.51) | PIK3R2 | |
| SCHEMBL19989801 | 0.81 | PIK3R2 (0.61) | PIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227350-B2 | Phosphatidylinositol 3-kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| US-20180086768-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227350-B2 | Phosphatidylinositol 3-kinase inhibitors | PIK3CA, AKT3, AKT1 | PIK3R2 13/4885PIK3C3 76/4885 |
| US-20180086768-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PIK3CA, AKT3, AKT1 | PIK3R2 13/4885PIK3C3 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.