Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19989975 | 0.91 | SYK (0.41) | SYKPIK3R2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL19990120 | 0.90 | SYK (0.33) | SYKPIK3R2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL19989821 | 0.88 | SMN1; SMN2 (0.34) | SYKPIK3R2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL19989922 | 0.83 | SYK (0.38) | SYKAURKARPS6KB1GPR119MAP4K4 | |
| SCHEMBL19989758 | 0.80 | PIK3R2 (0.43) | PIK3R2SMN1; SMN2KDM4EALDH1A1HTT | |
| SCHEMBL19989865 | 0.79 | SYK (0.41) | SYKPIK3R2ATR | |
| SCHEMBL19989869 | 0.79 | PIK3R2 (0.45) | PIK3R2SMN1; SMN2KDM4EALDH1A1HTT | |
| SCHEMBL19989780 | 0.78 | SMN1; SMN2 (0.38) | PIK3R2SMN1; SMN2KDM4EALDH1A1HTT | |
| SCHEMBL19989903 | 0.77 | PRMT1 (0.33) | SYKSMN1; SMN2ALDH1A1AURKARPS6KB1 | |
| SCHEMBL19989837 | 0.75 | PIK3R2 (0.48) | PIK3R2SMN1; SMN2KDM4EALDH1A1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227350-B2 | Phosphatidylinositol 3-kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| US-20180086768-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227350-B2 | Phosphatidylinositol 3-kinase inhibitors | PIK3CA, AKT3, AKT1 | SYK 531/4885PIK3R2 13/4885SMN1; SMN2 1760/4885 |
| US-20180086768-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PIK3CA, AKT3, AKT1 | SYK 531/4885PIK3R2 13/4885SMN1; SMN2 1760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.