Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.39 |
| ▸ | HPRT1 | P00492 | 11/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19994972 | 1.00 | SLC29A1 (0.39) | SLC29A1HPRT1CYP2C19HSP90AA1HSP90AB1 | |
| SCHEMBL19994279 | 0.91 | HPRT1 (0.45) | SLC29A1HPRT1HSP90AA1HSP90AB1CYP1A2 | |
| SCHEMBL19994282 | 0.91 | HPRT1 (0.45) | SLC29A1HPRT1HSP90AA1HSP90AB1CYP1A2 | |
| SCHEMBL20012093 | 0.91 | HPRT1 (0.45) | SLC29A1HPRT1HSP90AA1HSP90AB1CYP1A2 | |
| SCHEMBL20012074 | 0.90 | SLC29A1 (0.38) | SLC29A1HPRT1CYP2C19HSP90AA1HSP90AB1 | |
| SCHEMBL20012087 | 0.90 | SLC29A1 (0.38) | SLC29A1HPRT1CYP2C19HSP90AA1HSP90AB1 | |
| SCHEMBL20012073 | 0.83 | SLC29A1 (0.39) | SLC29A1HPRT1CYP2C19HSP90AA1HSP90AB1 | |
| SCHEMBL19994721 | 0.80 | HPRT1 (0.46) | HPRT1HSP90AA1HSP90AB1 | |
| SCHEMBL7131234 | 0.79 | CYP3A4 (0.53) | SLC29A1HPRT1CYP1A2CYP2D6CYP3A4 | |
| SCHEMBL20012357 | 0.79 | CYP3A4 (0.53) | SLC29A1HPRT1CYP1A2CYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515923-A1 | PRODRUGS OF FLUORINATED ACYCLIC NUCLEOSIDE PHOSPHONATES | Katholieke Universiteit Leuven (BE) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018055071-A1 | PRODRUGS OF FLUORINATED ACYCLIC NUCLEOSIDE PHOSPHONATES | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2018-03-29 | — | — | WO | disclosed |