Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.55 |
| ▸ | EGFR | P00533 | 8/20 | 0.55 |
| ▸ | SRC | P12931 | 3/20 | 0.51 |
| ▸ | TEC | P42680 | 3/20 | 0.47 |
| ▸ | BMX | P51813 | 3/20 | 0.47 |
| ▸ | TXK | P42681 | 2/20 | 0.47 |
| ▸ | LYN | P07948 | 2/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.47 |
| ▸ | ITK | Q08881 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.47 |
| ▸ | LATS1 | O95835 | 1/20 | 0.47 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18889455 | 0.86 | BTK (0.74) | BTKEGFRSRC | |
| SCHEMBL15756407 | 0.85 | BTK (0.75) | BTKEGFRSRCTECBMX | |
| SCHEMBL17181775 | 0.85 | BTK (0.75) | BTKEGFRSRCTECBMX | |
| SCHEMBL28025120 | 0.79 | BTK (0.50) | BTKEGFRSRCITKLCK | |
| SCHEMBL15756478 | 0.79 | BTK (0.55) | BTKEGFRSRCITKLCK | |
| SCHEMBL15756477 | 0.79 | BTK (0.55) | BTKEGFRSRCITKLCK | |
| SCHEMBL20007619 | 0.78 | BTK (0.74) | BTK | |
| SCHEMBL17181755 | 0.77 | BTK (0.49) | BTKEGFRSRC | |
| SCHEMBL17181756 | 0.77 | BTK (0.49) | BTKEGFRSRC | |
| SCHEMBL21398244 | 0.76 | BTK (0.73) | BTKEGFRSRCTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926299-B2 | Inhibitors of bruton's tyrosine kinase | CENTAURUS BIOPHARMA CO., LTD. (CN) | 2018-03-27 | — | — | US | disclosed |