Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.59 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | NSD2 | O96028 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18095861 | 0.91 | CTNNB1 (0.65) | CTNNB1TCF7L2MEN1KMT2APOLB | |
| SCHEMBL18102989 | 0.91 | CTNNB1 (0.65) | CTNNB1TCF7L2MEN1KMT2APOLB | |
| SCHEMBL18095863 | 0.91 | CTNNB1 (0.65) | CTNNB1TCF7L2MEN1KMT2APOLB | |
| SCHEMBL18095816 | 0.90 | CTNNB1 (0.58) | CTNNB1TCF7L2MEN1KMT2ALMNA | |
| SCHEMBL18095817 | 0.90 | CTNNB1 (0.58) | CTNNB1TCF7L2MEN1KMT2ALMNA | |
| SCHEMBL18103066 | 0.90 | CTNNB1 (0.58) | CTNNB1TCF7L2MEN1KMT2ALMNA | |
| SCHEMBL18095807 | 0.89 | MEN1 (0.59) | CTNNB1TCF7L2MEN1KMT2ALMNA | |
| SCHEMBL18102969 | 0.89 | CTNNB1 (0.56) | CTNNB1TCF7L2MEN1KMT2ALMNA | |
| SCHEMBL19991290 | 0.89 | CTNNB1 (0.56) | CTNNB1TCF7L2MEN1KMT2ALMNA | |
| SCHEMBL18103068 | 0.89 | CTNNB1 (0.56) | CTNNB1TCF7L2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NOTCH1, CBFB, HES1 | CTNNB1 551/4885TCF7L2 15/4885MEN1 846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.