Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAT1 | P18440 | 3/20 | 0.81 |
| ▸ | GSK3B | P49841 | 1/20 | 0.75 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.68 |
| ▸ | PTP4A3 | O75365 | 4/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309670 | 0.90 | NAT1 (1.00) | NAT1GSK3BPDE4BPTP4A3CA2 | |
| SCHEMBL8309671 | 0.90 | NAT1 (1.00) | NAT1GSK3BPDE4BPTP4A3CA2 | |
| SCHEMBL18103028 | 0.88 | NAT1 (0.85) | NAT1GSK3BPDE4BPTP4A3CA2 | |
| SCHEMBL18102857 | 0.86 | GSK3B (0.77) | NAT1GSK3BPDE4BPTP4A3MEN1 | |
| SCHEMBL18102849 | 0.85 | GSK3B (0.75) | NAT1GSK3BPDE4BPTP4A3CISD1 | |
| SCHEMBL18103046 | 0.84 | GSK3B (0.73) | NAT1GSK3BPDE4BPTP4A3CA2 | |
| SCHEMBL29518134 | 0.82 | GSK3B (0.66) | NAT1GSK3BPDE4BPTP4A3CA2 | |
| SCHEMBL18102860 | 0.82 | GSK3B (0.73) | NAT1GSK3BPDE4BPTP4A3CA2 | |
| SCHEMBL10090211 | 0.81 | PTP4A3 (0.83) | NAT1GSK3BPTP4A3CISD1MEN1 | |
| SCHEMBL2064980 | 0.81 | PTP4A3 (0.83) | NAT1GSK3BPTP4A3CISD1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10501413-B2 | Inhibitors of the Notch transcriptional activation complex and methods for use of the same | UNIVERSITY OF MIAMI (US) | 2019-12-10 | — | — | US | disclosed |
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-03-29 | — | — | US | disclosed |
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10501413-B2 | Inhibitors of the Notch transcriptional activation complex and methods for use of the same | NOTCH1, CBFB, HES1 | NAT1 867/4885GSK3B 1070/4885PDE4B 3826/4885 |
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NOTCH1, CBFB, HES1 | NAT1 867/4885GSK3B 1070/4885PDE4B 3826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.