Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 19/20 | 1.00 |
| ▸ | SRC | P12931 | 15/20 | 1.00 |
| ▸ | TEK | Q02763 | 12/20 | 1.00 |
| ▸ | FYN | P06241 | 4/20 | 1.00 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.89 |
| ▸ | PLK4 | O00444 | 2/20 | 0.89 |
| ▸ | AURKA | O14965 | 2/20 | 0.89 |
| ▸ | PAK4 | O96013 | 2/20 | 0.89 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.89 |
| ▸ | EGFR | P00533 | 2/20 | 0.89 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.89 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.89 |
| ▸ | INSR | P06213 | 2/20 | 0.89 |
| ▸ | CSF1R | P07333 | 2/20 | 0.89 |
| ▸ | LYN | P07948 | 2/20 | 0.89 |
| ▸ | FLT1 | P17948 | 2/20 | 0.89 |
| ▸ | NEK2 | P51955 | 2/20 | 0.89 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.89 |
| ▸ | STK3 | Q13188 | 2/20 | 0.89 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31061271 | 1.00 | LCK (1.00) | LCKSRCTEKFYNLIMK1 | |
| SCHEMBL6221049 | 1.00 | LCK (1.00) | LCKSRCTEKFYNLIMK1 | |
| SCHEMBL5803074 | 1.00 | LCK (1.00) | LCKSRCTEKFYNLIMK1 | |
| SCHEMBL29457687 | 1.00 | LCK (1.00) | LCKSRCTEKFYNLIMK1 | |
| SCHEMBL16752208 | 1.00 | LCK (1.00) | LCKSRCTEKFYNLIMK1 | |
| SCHEMBL30521863 | 1.00 | LCK (1.00) | LCKSRCTEKFYNLIMK1 | |
| SCHEMBL14106773 | 1.00 | LCK (1.00) | LCKSRCTEKFYNLIMK1 | |
| SCHEMBL6435493 | 0.94 | LCK (0.89) | LCKSRCTEKFYNLIMK1 | |
| SCHEMBL29562158 | 0.94 | LCK (1.00) | LCKSRCTEKFYNLIMK1 | |
| SCHEMBL29584810 | 0.94 | LCK (1.00) | LCKSRCTEKFYNLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2878601-B1 | AGENT FOR TREATING OR CONTROLLING RECURRENCE OF ACUTE MYELOGENOUS LEUKEMIA | RIKEN (JP) | 2018-03-28 | — | — | EP | disclosed |
| US-7400979-B2 | Kinase inhibitors; genetic engineering | ABBOTT LABORATORIES (US) | 2008-07-15 | — | — | US | disclosed |
| US-7400979-B2 | Kinase inhibitors; genetic engineering | ABBOTT LABORATORIES (US) | 2008-07-15 | — | — | US | disclosed |