Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R2 | O00459 | 20/20 | 0.75 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.75 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.75 |
| ▸ | PIK3R1 | P27986 | 11/20 | 0.75 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.75 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20001525 | 0.93 | PIK3R2 (0.68) | PIK3R2PIK3CBPIK3CDPIK3R1PIK3CA | |
| SCHEMBL20001526 | 0.92 | PIK3R2 (0.75) | PIK3R2PIK3CBPIK3CDPIK3R1PIK3CA | |
| SCHEMBL20010396 | 0.89 | PIK3R2 (0.77) | PIK3R2PIK3CBPIK3CDPIK3R1PIK3CA | |
| SCHEMBL20001371 | 0.87 | PIK3R2 (0.74) | PIK3R2PIK3CBPIK3CDPIK3R1PIK3CA | |
| SCHEMBL20001549 | 0.86 | PIK3R2 (0.76) | PIK3R2PIK3CBPIK3CDPIK3R1PIK3CA | |
| SCHEMBL20001366 | 0.85 | PIK3R2 (0.78) | PIK3R2PIK3CBPIK3CDPIK3R1PIK3CA | |
| SCHEMBL20010498 | 0.83 | PIK3R2 (0.79) | PIK3R2PIK3CBPIK3CDPIK3R1PIK3CA | |
| SCHEMBL20001381 | 0.80 | PIK3R2 (0.67) | PIK3R2PIK3CBPIK3CDPIK3R1PIK3CA | |
| SCHEMBL20001377 | 0.80 | PIK3R2 (0.65) | PIK3R2PIK3CBPIK3CDPIK3R1PIK3CA | |
| SCHEMBL20001470 | 0.80 | PIK3R2 (0.78) | PIK3R2PIK3CBPIK3CDPIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018057810-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2018-03-29 | — | — | WO | disclosed |