Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002146 | 1.00 | USP30 (0.39) | USP30RORCNR1H2NR1H3CASP1 | |
| SCHEMBL21527884 | 0.92 | USP30 (0.39) | USP30RORCNR1H2NR1H3CASP1 | |
| SCHEMBL20005754 | 0.92 | USP30 (0.39) | USP30RORCNR1H2NR1H3CASP1 | |
| SCHEMBL20002177 | 0.92 | USP30 (0.39) | USP30RORCNR1H2NR1H3CASP1 | |
| SCHEMBL21527882 | 0.92 | USP30 (0.39) | USP30RORCNR1H2NR1H3CASP1 | |
| SCHEMBL21527883 | 0.92 | USP30 (0.39) | USP30RORCNR1H2NR1H3CASP1 | |
| SCHEMBL21137019 | 0.90 | APP (0.40) | RORCNR1H2NR1H3CASP1KDM1A | |
| SCHEMBL29483985 | 0.90 | APP (0.40) | RORCNR1H2NR1H3CASP1KDM1A | |
| SCHEMBL19995975 | 0.90 | APP (0.40) | RORCNR1H2NR1H3CASP1KDM1A | |
| SCHEMBL21527835 | 0.89 | USP30 (0.38) | USP30NR1H2NR1H3CASP1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018056855-A1 | DOPAMINE-B-HYDROXYLASE INHIBITORS | BIAL - PORTELA & Cª, S.A. (PT) | 2018-03-29 | — | — | WO | disclosed |