Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLR1A | O95602 | 19/20 | 0.76 |
| ▸ | ECE1 | P42892 | 1/20 | 0.76 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | PKM | P14618 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003190 | 0.89 | POLR1A (0.80) | POLR1AECE1MUS81KDM4EMEN1 | |
| SCHEMBL13984171 | 0.88 | POLR1A (0.78) | POLR1AECE1MUS81KDM4EMEN1 | |
| SCHEMBL25761777 | 0.87 | KDM4E (0.81) | POLR1AECE1MUS81KDM4EMEN1 | |
| SCHEMBL18650616 | 0.87 | POLR1A (0.82) | POLR1AECE1MUS81KDM4EMEN1 | |
| SCHEMBL22421609 | 0.86 | POLR1A (0.75) | POLR1AECE1MUS81KDM4EMEN1 | |
| SCHEMBL25761631 | 0.86 | KDM4E (0.80) | POLR1AECE1MUS81KDM4EMEN1 | |
| SCHEMBL13248367 | 0.86 | POLR1A (1.00) | POLR1AECE1MUS81KDM4EMEN1 | |
| SCHEMBL17099665 | 0.85 | POLR1A (1.00) | POLR1AECE1MUS81KDM4EMEN1 | |
| SCHEMBL17099668 | 0.85 | POLR1A (1.00) | POLR1A | |
| SCHEMBL22421594 | 0.85 | POLR1A (0.72) | POLR1AECE1MUS81KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515448-B1 | COMBINATORY TREATMENT STRATEGIES OF CANCER BASED ON RNA POLYMERASE I INHIBITION | UNIV JOHNS HOPKINS (US) | 2023-07-05 | — | — | EP | disclosed |
| EP-3778600-A1 | COMPOUNDS WHICH INHIBIT RNA POLYMERASE, COMPOSITIONS INCLUDING SUCH COMPOUNDS, AND THEIR USE | The Johns Hopkins University (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3119781-B1 | COMPOUNDS WHICH INHIBIT RNA POLYMERASE, COMPOSITIONS INCLUDING SUCH COMPOUNDS, AND THEIR USE | UNIV JOHNS HOPKINS (US) | 2020-09-16 | — | — | EP | disclosed |
| WO-2018057834-A1 | COMBINATORY TREATMENT STRATEGIES OF CANCER BASED ON RNA POLYMERASE I INHIBITION | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-03-29 | — | — | WO | disclosed |