⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10093881 | 0.78 | TSHR (0.32) | — | |
| SCHEMBL23902277 | 0.77 | — | — | |
| SCHEMBL9768707 | 0.77 | — | — | |
| SCHEMBL12884948 | 0.76 | — | — | |
| SCHEMBL23750601 | 0.75 | — | — | |
| SCHEMBL23612901 | 0.73 | — | — | |
| SCHEMBL23612897 | 0.73 | — | — | |
| SCHEMBL23901755 | 0.73 | MEN1 (0.37) | — | |
| SCHEMBL14525844 | 0.72 | — | — | |
| SCHEMBL24595677 | 0.72 | TSHR (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234955-A1 | METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS | ARRAY BIOPHARMA INC (US) | 2023-07-27 | — | — | US | disclosed |
| US-20180086757-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |