Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.52 |
| ▸ | KDR | P35968 | 6/20 | 0.51 |
| ▸ | KIT | P10721 | 4/20 | 0.51 |
| ▸ | INSR | P06213 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20004720 | 0.85 | ALK (0.53) | ALKKDRINSR | |
| SCHEMBL897524 | 0.72 | ALK (0.94) | ALKKDRKITINSR | |
| SCHEMBL896850 | 0.69 | ALK (1.00) | ALKKDRKITINSR | |
| SCHEMBL10283152 | 0.68 | ALK (0.83) | ALKKDRKITINSRABL1 | |
| SCHEMBL897652 | 0.68 | ALK (0.79) | ALKKDRKITINSRABL1 | |
| SCHEMBL896738 | 0.68 | ALK (1.00) | ALKKDRKITINSRABL1 | |
| SCHEMBL21443145 | 0.68 | ALK (0.47) | ALK | |
| SCHEMBL897341 | 0.68 | ALK (1.00) | ALKKDRKITINSRABL1 | |
| SCHEMBL897307 | 0.68 | ALK (1.00) | ALKKDRKITINSRABL1 | |
| SCHEMBL897444 | 0.68 | ALK (1.00) | ALKKDRKITINSRABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975024-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-03-28 | — | — | EP | disclosed |