SCHEMBL20004127

SCHEMBL20004127

Cc1cc2c(cc1OC[C@H](O)CO)C(C)(C)c1[nH]c3cc(Cl)ccc3c1C2=O

nearest known ligand 0.83

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
ALK Q9UM73 20/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL897588 0.91 ALK (1.00) ALK
SCHEMBL897591 0.91 ALK (1.00) ALK
SCHEMBL897590 0.91 ALK (1.00) ALK
SCHEMBL897462 0.90 ALK (0.82) ALK
SCHEMBL17636132 0.90 ALK (0.82) ALK
SCHEMBL897464 0.90 ALK (0.82) ALK
SCHEMBL897463 0.90 ALK (0.82) ALK
SCHEMBL898420 0.90 ALK (0.78) ALK
SCHEMBL898419 0.90 ALK (0.78) ALK
SCHEMBL898421 0.90 ALK (0.78) ALK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2975024-B1 TETRACYCLIC COMPOUNDS CHUGAI PHARMACEUTICAL CO LTD (JP) 2018-03-28 EP disclosed