SCHEMBL20004174

SCHEMBL20004174

C#Cc1ccc2c3c([nH]c2c1)C(C)(C)c1cc(S(=O)(=O)CC(O)CO)ccc1C3=O

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALK Q9UM73 19/20 0.59
SRPK1 Q96SB4 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL897619 0.91 ALK (0.71) ALKSRPK1
SCHEMBL24676154 0.82 ALK (0.49) ALK
SCHEMBL20366509 0.76 ALK (0.68) ALK
SCHEMBL1703505 0.75 ALK (0.73) ALKSRPK1
SCHEMBL897371 0.74 ALK (1.00) ALKSRPK1
SCHEMBL896662 0.73 ALK (0.87) ALK
SCHEMBL896660 0.73 ALK (0.87) ALK
SCHEMBL896967 0.73 ALK (0.70) ALKSRPK1
SCHEMBL897063 0.73 ALK (1.00) ALKSRPK1
SCHEMBL896663 0.73 ALK (0.87) ALK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2975024-B1 TETRACYCLIC COMPOUNDS CHUGAI PHARMACEUTICAL CO LTD (JP) 2018-03-28 EP disclosed