SCHEMBL20004604

SCHEMBL20004604

C=c1[nH]c(C#Cc2ccc(N(C)CCF)cc2)c/c1=C/C=C(\N)N1CCOCC1

nearest known ligand 0.42

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.42
SNCA P37840 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20005075 0.70 SNCA (0.60) MAPTSNCA
SCHEMBL21115287 0.70 SNCA (0.60) MAPTSNCA
SCHEMBL20004625 0.67 SNCA (0.61) MAPTSNCA
SCHEMBL20005181 0.66 SNCA (0.46) MAPTSNCA
SCHEMBL20004652 0.64 MAPT (0.43) MAPTSNCA
SCHEMBL22537751 0.63 MAPT (0.46) MAPTSNCA
SCHEMBL22537604 0.63 MAPT (0.41) MAPTSNCA
SCHEMBL22537746 0.61 SNCA (0.48) MAPTSNCA
SCHEMBL22537754 0.60 SNCA (0.52) MAPTSNCA
SCHEMBL20004553 0.60 SNCA (1.00) MAPTSNCA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018055316-A1 COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2018-03-29 WO disclosed