Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 17/20 | 0.70 |
| ▸ | SRPK1 | Q96SB4 | 6/20 | 0.53 |
| ▸ | SRPK2 | P78362 | 4/20 | 0.51 |
| ▸ | EML4 | Q9HC35 | 3/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20004130 | 0.83 | ALK (0.73) | ALKSRPK1SRPK2EML4 | |
| SCHEMBL20366485 | 0.82 | ALK (0.69) | ALKSRPK1SRPK2EML4 | |
| SCHEMBL897610 | 0.82 | ALK (0.72) | ALKSRPK1SRPK2EML4 | |
| SCHEMBL897203 | 0.82 | ALK (1.00) | ALKSRPK1SRPK2EML4DYRK3 | |
| SCHEMBL897390 | 0.80 | ALK (0.77) | ALKSRPK1SRPK2EML4DYRK3 | |
| SCHEMBL20004101 | 0.80 | ALK (0.64) | ALKSRPK1SRPK2EML4 | |
| SCHEMBL897528 | 0.78 | ALK (0.92) | ALKSRPK1SRPK2EML4 | |
| SCHEMBL10283126 | 0.78 | ALK (0.78) | ALKSRPK1SRPK2EML4 | |
| SCHEMBL897185 | 0.78 | ALK (0.79) | ALKSRPK1SRPK2EML4 | |
| SCHEMBL16775671 | 0.78 | ALK (0.78) | ALKSRPK1SRPK2EML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3345903-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2019-10-09 | — | — | EP | disclosed |
| EP-2975024-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-03-28 | — | — | EP | disclosed |