Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA4 | P22748 | 3/20 | 0.41 |
| ▸ | CA6 | P23280 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755993 | 0.81 | CA1 (0.48) | CA1CA2CA4CA6KDM4E | |
| SCHEMBL897691 | 0.78 | ALK (0.50) | ALK | |
| SCHEMBL21443127 | 0.77 | ALK (0.49) | KDM4EMAPTPOLBGAAKMT2A | |
| SCHEMBL896972 | 0.73 | CDK4 (0.46) | CA1CA2CA4CA6KDM4E | |
| SCHEMBL897959 | 0.73 | CA1 (0.43) | CA1CA2CA4CA6KDM4E | |
| SCHEMBL20004253 | 0.71 | CA1 (0.32) | CA1CA2CA4CA6ALK | |
| SCHEMBL23027947 | 0.70 | CA1 (0.45) | CA1CA2CA4CA6KDM4E | |
| SCHEMBL897447 | 0.70 | CA1 (0.43) | CA1CA2CA4CA6KDM4E | |
| SCHEMBL898273 | 0.69 | CA1 (0.41) | CA1CA2CA4CA6KDM4E | |
| SCHEMBL21613391 | 0.69 | CA1 (0.40) | CA1CA2CA4CA6HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975024-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-03-28 | — | — | EP | disclosed |