Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 13/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.45 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.45 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1885517 | 0.91 | CRACR2A (1.00) | CRACR2AKMT2ANPC1TRPC3ORAI1 | |
| SCHEMBL12638101 | 0.87 | CRACR2A (0.87) | CRACR2AKMT2ANPC1TRPC3ORAI1 | |
| SCHEMBL1668804 | 0.84 | CRACR2A (0.80) | CRACR2AKMT2ANPC1TRPC3ORAI1 | |
| SCHEMBL12638058 | 0.83 | CRACR2A (0.84) | CRACR2AKMT2ANPC1 | |
| SCHEMBL1668163 | 0.83 | CRACR2A (1.00) | CRACR2AORAI1 | |
| SCHEMBL1668602 | 0.80 | CRACR2A (1.00) | CRACR2ATRPC3ORAI1TRPC5 | |
| SCHEMBL20006585 | 0.71 | CRACR2A (0.82) | CRACR2ATRPC3ORAI1TRPC5 | |
| SCHEMBL12637950 | 0.70 | CRACR2A (0.83) | CRACR2AKMT2ATRPC3ORAI1TRPC5 | |
| SCHEMBL1668056 | 0.69 | CRACR2A (1.00) | CRACR2ATRPC3ORAI1TRPC5LMNA | |
| SCHEMBL14442458 | 0.69 | POLB (0.62) | CRACR2AKMT2ANPC1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299361-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | Rhizen Pharmaceuticals S.A. (CH) | 2018-03-28 | — | — | EP | disclosed |