Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21494327 | 0.89 | HTT (0.43) | HTTTSHRALDH1A1MALT1MAPK1 | |
| SCHEMBL21512512 | 0.82 | HTT (0.41) | HTTTSHRALDH1A1MALT1MAPK1 | |
| SCHEMBL29969729 | 0.82 | HTT (0.41) | HTTTSHRALDH1A1MALT1MAPK1 | |
| SCHEMBL20006130 | 0.80 | LRRK2 (0.31) | — | |
| SCHEMBL10282246 | 0.77 | HTT (0.64) | HTTTSHRALDH1A1MALT1MAPK1 | |
| SCHEMBL20495103 | 0.74 | HTT (0.53) | HTTTSHRALDH1A1MAPK1RXFP1 | |
| SCHEMBL26131455 | 0.72 | HTT (0.41) | HTTTSHRALDH1A1MAPK1RXFP1 | |
| SCHEMBL22410703 | 0.71 | MALT1 (0.56) | HTTTSHRALDH1A1MALT1MAPK1 | |
| SCHEMBL21494424 | 0.69 | HTT (0.46) | HTTTSHRALDH1A1MALT1MAPK1 | |
| SCHEMBL1557613 | 0.69 | TNF (0.42) | HTTTSHRALDH1A1MALT1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3140303-B1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2018-03-28 | — | — | EP | disclosed |