Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 20/20 | 0.85 |
| ▸ | MTOR | P42345 | 15/20 | 0.85 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.85 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.84 |
| ▸ | ATR | Q13535 | 3/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17246310 | 0.92 | ATM (1.00) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL17242591 | 0.92 | ATM (1.00) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL17272523 | 0.92 | ATM (1.00) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL20006433 | 0.92 | ATM (1.00) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL17241603 | 0.92 | ATM (1.00) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL21129784 | 0.92 | ATM (1.00) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL17272551 | 0.92 | ATM (1.00) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL20006507 | 0.89 | ATM (0.84) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL17272564 | 0.88 | ATM (0.94) | ATMMTORPIK3CAKCNH2ATR | |
| SCHEMBL17246505 | 0.87 | ATM (0.73) | ATMMTORPIK3CAKCNH2ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3140303-B1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2018-03-28 | — | — | EP | disclosed |