SCHEMBL20006840

SCHEMBL20006840

COc1cc(-c2ccc(-c3ccc(O)cc3F)cc2F)cc(F)c1C#Cc1cc(F)c(C(F)(F)Oc2cc(F)c(F)c(F)c2)c(F)c1

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 2/20 0.37
ESR1 P03372 2/20 0.36
ESR2 Q92731 2/20 0.36
ABCB1 P08183 1/20 0.33
AKR1C3 P42330 1/20 0.30
AKR1C2 P52895 1/20 0.30
HSD17B1 P14061 1/20 0.30
HSD17B2 P37059 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19999604 0.91 ERN1 (0.33) ERN1
SCHEMBL20006839 0.91 ERN1 (0.36) ERN1
SCHEMBL20006712 0.88 ESR1 (0.33) ERN1ESR1ESR2
SCHEMBL20005253 0.87 ERN1 (0.32) ERN1
SCHEMBL19999606 0.85 RARB (0.33)
SCHEMBL19999638 0.83 ERN1 (0.30) ERN1
SCHEMBL14241280 0.82 ESR1 (0.45) ERN1ESR1ESR2AKR1C3HSD17B1
SCHEMBL20004801 0.80
SCHEMBL20004799 0.80
SCHEMBL20005265 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10208249-B2 Liquid crystal compound, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2019-02-19 US disclosed
US-20180086979-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2018-03-29 US disclosed