Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17237026 | 0.96 | KRAS (0.65) | KRASPOLBGAACXCL12MEN1 | |
| SCHEMBL17237029 | 0.96 | KRAS (0.65) | KRASPOLBGAACXCL12MEN1 | |
| SCHEMBL17237164 | 0.93 | KRAS (0.71) | KRASPOLBGAAMEN1KMT2A | |
| SCHEMBL17237168 | 0.93 | KRAS (0.71) | KRASPOLBGAAMEN1KMT2A | |
| SCHEMBL20007046 | 0.88 | POLB (0.67) | KRASPOLBGAACXCL12MEN1 | |
| SCHEMBL17237423 | 0.88 | ABCG2 (0.55) | KRASMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL17237422 | 0.88 | ABCG2 (0.55) | KRASMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL17251600 | 0.87 | CA1 (0.65) | KRASGAACXCL12MEN1KMT2A | |
| SCHEMBL17236730 | 0.87 | KRAS (0.57) | KRASPOLBGAAMEN1KMT2A | |
| SCHEMBL17236731 | 0.87 | KRAS (0.57) | KRASPOLBGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2942345-B1 | 3,4,5-TRIMETHOXYSTYRYLARYLAMINOPROPENONES FOR THE TREATMENT OF CANCER | COUNCIL SCIENT IND RES (IN) | 2018-03-28 | — | — | EP | disclosed |