Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.63 |
| ▸ | RAF1 | P04049 | 18/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17523485 | 0.83 | RAF1 (0.84) | BRAFRAF1 | |
| SCHEMBL17523488 | 0.80 | RAF1 (0.84) | BRAFRAF1 | |
| SCHEMBL17523482 | 0.78 | BRAF (0.81) | BRAFRAF1 | |
| SCHEMBL16094188 | 0.77 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL20008439 | 0.75 | RAF1 (0.67) | BRAFRAF1 | |
| SCHEMBL20008273 | 0.73 | BRAF (0.51) | BRAFRAF1 | |
| SCHEMBL20010310 | 0.73 | BRAF (0.53) | BRAFRAF1 | |
| SCHEMBL20008245 | 0.70 | BRAF (0.71) | BRAFRAF1 | |
| SCHEMBL16094271 | 0.69 | RAF1 (1.00) | BRAFRAF1 | |
| SCHEMBL20009145 | 0.68 | RAF1 (0.57) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |