Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 6/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.42 |
| ▸ | MTOR | P42345 | 3/20 | 0.42 |
| ▸ | BRAF | P15056 | 9/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16121452 | 0.88 | BRAF (0.54) | RAF1PIK3CAMTORBRAF | |
| SCHEMBL16094681 | 0.86 | BRAF (0.55) | RAF1PIK3CABRAFNUDT1KDM4E | |
| SCHEMBL16095126 | 0.82 | RAF1 (0.52) | RAF1PIK3CAPIK3R1MTORBRAF | |
| SCHEMBL16094893 | 0.81 | BRAF (0.56) | RAF1MTORBRAFNUDT1KDM4E | |
| SCHEMBL16094722 | 0.81 | RAF1 (0.59) | RAF1PIK3CABRAF | |
| SCHEMBL25594314 | 0.77 | RAF1 (0.63) | RAF1PIK3CABRAFCRHBPCRHR2 | |
| SCHEMBL16121173 | 0.77 | RAF1 (0.48) | RAF1PIK3CAPIK3R1MTORBRAF | |
| SCHEMBL16121597 | 0.74 | RAF1 (0.57) | RAF1BRAF | |
| SCHEMBL2144542 | 0.74 | KDM4E (0.46) | RAF1PIK3CAPIK3R1MTORNUDT1 | |
| SCHEMBL26783363 | 0.73 | RAF1 (0.58) | RAF1PIK3CAMTORBRAFCRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |