Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.56 |
| ▸ | RAF1 | P04049 | 15/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.45 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008245 | 0.77 | BRAF (0.71) | BRAFRAF1 | |
| SCHEMBL20009438 | 0.73 | RAF1 (0.52) | BRAFRAF1 | |
| SCHEMBL16036680 | 0.72 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL16036681 | 0.72 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL20008439 | 0.70 | RAF1 (0.67) | BRAFRAF1 | |
| SCHEMBL20009394 | 0.68 | BRAF (0.70) | BRAFRAF1MAPK14 | |
| SCHEMBL16037016 | 0.67 | RAF1 (1.00) | BRAFRAF1 | |
| SCHEMBL16037015 | 0.67 | RAF1 (1.00) | BRAFRAF1 | |
| SCHEMBL16078165 | 0.67 | RAF1 (1.00) | BRAFRAF1 | |
| SCHEMBL16103445 | 0.67 | RAF1 (1.00) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |